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In vivo neutralization of human and cynomolgus IL‑1α (left panel) and IL‑1β (right panel) with ABT‑981. A pharmacodynamic mouse model was established to demonstrate in vivo activity of ABT-981. Upon injection with 30 ng of either human (•) or cynomolgus (5) IL‑1α and IL‑1β, mouse IL-6 was measured in serum. The loss of IL-6 in serum was correlated to the dose of ABT-981 given to each animal and a percent inhibition by ABT-981 was calculated.
