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Knock-down of AKT is synergistic with mTORC1/2 inhibition. (A) Knockdown of AKT1 and AKT2 in Huh7 cells was confirmed by Western blot, HSC70 served as loading control. (B) Huh7 SCR and AKT1/2 knockdown cells were incubated with DMSO, 2 µM MK-2206, 100 nM AZD8055, or a combination of both over 72h. After 72h cells were trypsinized and counted, and the relative increase in cell number in given in the graph. The Experiments were performed in triplicates. Bars: SD; #, p < 0.01
