Table 2.
Down-regulated circulating miRNA in GC
| Author | miRNA | Samples | Methods | Proportion | Usage |
|---|---|---|---|---|---|
| Chen Q[42] | miR-122 | 12 pairs of blood samples | qRT-PCR | AUC for plasma miR-122 was 0.808, 95% CI 0.712-0.905,P<0.01 | miR-122 down-regulated in GC, higher miR-122 may indicate a favorable prognosis |
| Zhang WH[68] | miR-375 | Microarray, qRT-PCR | miR-375 ROC 0.835, specificity 80%, sensitivity 85% | Biomarker for distal GC | |
| Gorur A[71] | miR-195-5p | 20 blood samples from GC patients and 190 volunteers | q RT-PCR | miR-195-5p down-regulated 13.3 fold, P<0.05 | miR-195-5p was a tumor suppressor miRNA and may contribute to gastric carcinogenesis |