Table 2.
Protein target candidates of bezafibrate identified by TarFisDoc
| No | PDB_ID | Energy score (kcal/mol) |
Target name | Related diseases |
|---|---|---|---|---|
| 1 | 2AGT | -38.21 | aldehyde reductase | diabetes |
| 2 | 1T41 | -38.09 | aldehyde reductase | diabetes |
| 3 | 1GAI | -38.01 | glucan 1,4-alpha-glucosidase | intestine disorder |
| 4 | 1FKN | -37.92 | memapsin 2 | Alzheimer's disease |
| 5 | 1HO4 | -37.82 | pyridoxine 5'-phosphate synthase | bacterial infections |
| 6 | 1LBV | -37.6 | inositol 1 phosphatase | affective disorder |
| 7 | 1J96 | -37.42 | aldo-keto reductase family 1 member c3 |
cancers |
| 8 | 2ADA | -36.8 | adenosine deaminas | leukemia |
| 9 | 1ADD | -36.73 | adenosine deaminase | leukemia |
| 10 | 1HDT | -36.4 | serine proteinase alpha-thrombin | haemostatic disorders |
| 11 | 1GZ8 | -36.32 | cyclin dependent kinase 2(Cdk2) | cancers |
| 12 | 2ANY | -35.89 | kallikrein | rheumatoid arthritis |
| 13 | 1K3Y | -35.25 | glutathione transferase A1-1 | cancers |
| 14 | 1HDT | -35.12 | serine proteinase alpha-thrombin | haemostatic disorders |
| 15 | 1JP7 | -34.99 | methylthioadenosine phosphorylase | leukemia |
| 16 | 1D4P | -34.92 | serine proteinase alpha-thrombin | haemostatic disorders |
| 17 | 1M4H | -34.52 | memapsin 2 | Alzheimer's disease |
| 18 | 1I76 | -34.32 | neutrophil collagenase, MMP | tumor invasion |