Table 1.
Glycoanalysis of 2G12 SIgA. Detected glycan structures on each chain of the SIgA complex. MS profiles are shown in supplemental Figure 2 Predominant glycan structures are marked with a +. The predicted glycan site SC4 was not detected in either of 2 assays. Glycan structure nomenclature available at http://www.proglycan.com/
| Chain | Glycosite | Peptide sequence | Structures |
|---|---|---|---|
| α | 263 | ANLTCTLTGLR | Man6 |
| Man7 | |||
| Man8+ | |||
| Man9 | |||
| α | 459 | LAGKPTHVNVSVVMAE | Man7 |
| Man8+ | |||
| Man9+ | |||
| GnGnXF | |||
| J | 71 | ENISDPTSPLR | Man6 |
| Man7 | |||
| Man8 | |||
| Man9 | |||
| MMXF+ | |||
| GnMXF+ | |||
| SC | 65 | ANLTNFPENGTFVVNIAQLSQDDSGR | Man8+ |
| Man9+ | |||
| SC | 72 | ANLTNFPENGTFVVNIAQLSQDDSGR | Man8+ |
| Man9+ | |||
| SC | 117 | VSQGPGLLNDTK | Man6 |
| Man7+ | |||
| Man8 | |||
| Man9 | |||
| SC | 168 | QIGLYPVLVIDSSGYVNPNYTGR | ND |
| SC | 403 | LSLLEEPGNGTFTVILNQLTSR | Man7 |
| Man8+ | |||
| Man9 | |||
| MMXF | |||
| MGnXF | |||
| GnGnXF | |||
| SC | 451 | VPGNVTAVLGETLK | Man8 |
| Man9 | |||
| MMXF | |||
| MGnXF | |||
| GnGnXF | |||
| SC | 481 | WNNTGCQALPSQDEGPSK | Man7 |
| Man8+ | |||
| Man9 |