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. 2014 Oct 29;15(11):1444–1455. doi: 10.4161/15384047.2014.955442

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

© Sandra L Romero-Cordoba, Ivan Salido-Guadarrama, Mauricio Rodriguez-Dorantes, and Alfredo Hidalgo-Miranda

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Several post-transcriptional mechanisms of miRNA biogenesis regulation. (A) Lin28 prevents the association of Drosha to the pri-miRNA let-7. (B) KSRP binds to the loop region and promotes Drosha processing. (C) Lin28 prevents the association of Dicer to the pre-miRNA let-7. (D) Lin28 promotes the association of TUT4 with the pre-miRNA let-7, enhancing the 3′ uridinylation of the pre-miRNA, and consequently its degradation. (E) KSRP binds to the loop region and promotes Dicer processing. (F) MAPK/ERK signaling modulates the expression or activity of Dicer, by promoting phosphorylation of TRBP. (G) The recognition of the 5′ monophosphate of the pre-miRNAs by Dicer is disrupted by the RNA-methyltransferase BCDIN3D, which phospho-dimethylates the pre-miR-145, and decreases miRNA processing by Dicer. (H) EGFR inhibits the processing of pre-miRNA through phosphorylation of AGO2-Y393, which attenuates the processing of pre-miRNAs to mature miRNAs under hypoxic conditions.