Table 3.

Association of protein expressions with clinicopathological characteristics

	cNHERF1		nNHERF1		cP-gp		mP-gp		cSR1		cHIF-1α		nHIF-1α
	(%)		(%)		(%)		(%)		(%)		(%)		(%)
Characteristics	neg.	pos.	neg.	pos.	neg.	pos.	neg.	pos.	neg.	pos.	neg.	pos.	neg.	pos.
Age (years)
< 62	41.7	56.3	53.8	46.7	25	60	47.1	54.5	50	50	38.5	60	57.1	42.9
≥ 62	58.3	43.8	46.2	53.3	75	40	52.9	45.5	50	50	61.5	40	42.9	57.1
P value	ns		ns		ns		ns		ns		ns		ns
Gender
Male	66.7	50	46.2	66.7	62.5	55	47.1	72.7	71.4	42.9	53.8	60	57.1	57.1
Female	33.3	50	53.8	33.3	37.5	45	52.9	27.3	28.6	57.1	46.2	40	42.9	42.9
P value	ns		ns	ns			ns		ns		ns		ns
Lauren type
Intestinal	50	80	50	80	62.5	68.4	50	90.9	64.3	69.2	38.5	92.9	69.2	64.3
Diffuse	50	20	50	20	37.5	31.6	50	9.1	35.7	30.8	61.5	7.1	30.8	35.7
P value	ns		ns		ns		0.042		ns		0.004		ns
Tumor differentiation
Moderate	9.1	20	23.1	7.7	0	20	13.3	18.2	0	28.6	0	26.7	7.1	25
Poor	90.9	80	76.9	92.3	100	80	86.7	81.8	100	71.4	100	73.3	92.9	75
P value	ns		ns		ns		ns		ns		ns		ns
Vascular invasion
Present	45.5	73.3	69.2	53.8	16.7	75	80	36.4	25	92.9	45.5	73.3	64.3	58.3
Absent	54.5	26.7	30.8	46.2	83.3	25	20	63.6	75	7.1	54.5	26.7	35.7	41.7
P value	ns		ns		0.018		0.043		0.001		ns		ns
Clinical response
DCR	50	37.5	15.4	66.7	62.5	35	47.1	36.4	57.1	28.6	53.8	33.3	28.6	57.1
PD	50	62.5	84.6	33.3	37.5	65	52.9	63.6	42.9	71.4	46.2	66.7	71.4	42.9
P value	ns		0.009		ns		ns		ns		ns		ns

Abbreviations: cNHERF1, cytoplasmic NHERF1; nNHERF1, nuclear NHERF1; cP-gp, cytoplasmic P-gp; mP-gp, membranous P-gp; cSR1, cytoplasmic SR1; cHIF-1α, cytoplasmic HIF-1α; nHIF-1α, nuclear HIF-1α; DCR, disease control rate; PD, progression diseas.

P-values were calculated with the Fisher's exact test.

Two patients out 28 had missing values for Tumor differentiation and Vascular invasion; one patient, classified as other histological type, was not included in the statistical analyses.