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. 2015 Jun 5;7(5):969–980. doi: 10.1080/19420862.2015.1055443

Figure 2.

Figure 2.

Predicted interaction mechanism of AIA22 with IFN-α2b and IFN-α1b. (A) The AIA22/IFN-α2b complex model. Variable region of AIA22 light chain (VL): green, variable region of heavy chain (VH): marine, IFN-α2b: pink. (B) The recognition region mapping of AIA22 (Green), IFNAR2 (Blue), and their overlapping region (Red) on IFN-α2b surface. (C) The predicted interaction interface between AIA22 and IFN-α2b. H1∼H3 and L1∼L3 represent the 6 CDR regions of heavy chain and light chain respectively. IFN-α2b and its residues are labeled as pink. The dotted lines between resides indicate hydrogen-bonds and solid lines indicate π interactions. (D) The predicted interaction interface between AIA22 and IFN-α1b. IFN-α1b and its residues were labeled as yellow. The atoms of Tyr99 (CDR H3) are displayed as CPK scale to clearly reveal its clash with IFN-α1b backbone residues Leu30 and Met31.