Table 3.

Neutralizing activities of monoclonal antibodies to multiple IFN-α subtypes

		Neutralizing Activity (EC50, nM)
IFN	Critical Concentration (IU/ml, pM)	AIA22	AIAmut	Sifalimumab
IFN-α1b	60, 36	335.90	49.66	18.71
IFN-α2b	0.5*, 25	0.63	0.24	1.80
IFN-α4b	150, 10.29	94.65	26.37	100.30
IFN-α5	100, 17.9	82.3	15.3	49.7
IFN-α6	200, 10.5	1.34	2.83	0.05
IFN-α7	200, 20.7	NA	NA	100.2
IFN-α8	70, 10	24.6	29.6	∼4.17§
IFN-α10	150, 51	335.4	76.85	188.4
IFN-α14	60, 25.4	28.4	246.4	∼2.0§
IFN-α16	30, 45	109.3	23.89	41.21
IFN-α17	100, 20.6	116.5	72.8	194.7
IFN-α21	100, 30	79.93	∼5.0§	44.43

^*The concentration unit is ng/ml.

^§The top and bottom value was not reached. NA = no activity.