Table 3.
Association relationship between hub genes with survival
| Training data set (n = 87) |
Validating dataset (n = 449) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| DMFS |
DMFS |
RFS |
|||||||
| Gene | HR | p-value | 95% CI | HR | p-value | 95% CI | HR | p-value | 95% CI |
| CDK1 | 2.92 | 8.5 × 10–3 | 1.31–6.49 | 3.07 | 3.0 × 10–5 | 1.81–5.21 | 2.13 | 1.3 × 10–5 | 1.52–3.00 |
| DEPDC1 | 3.34 | 4.1 × 10–3 | 1.47–7.62 | 0.93 | 7.9 × 10–1 | 0.54–1.58 | 0.98 | 8.9 V 10–1 | 0.71–1.35 |
| DLGAP5 | 2.86 | 9.9 × 10–3 | 1.29–6.35 | 1.98 | 7.8 × 10–3 | 1.20–3.26 | 1.77 | 8.2 × 10–4 | 1.27–2.47 |
| MELK | 3.52 | 2.4 × 10–3 | 1.54–8.05 | 2.55 | 2.9 × 10–4 | 1.54–4.24 | 1.97 | 8.9 × 10–5 | 1.40–2.77 |
| NUSAP1 | 2.97 | 7.6 × 10–3 | 1.34–6.62 | 2.35 | 9.2 × 10–4 | 1.42–3.89 | 1.43 | 3.6 × 10–2 | 1.02–1.99 |
| RRM2 | 2.86 | 9.8 × 10–3 | 1.29–6.36 | 1.85 | 1.6 × 10–2 | 1.12–3.06 | 2.04 | 3.9 × 10–5 | 1.45–2.86 |
Recurrence free survival (RFS), Distant metastasis free survival (DMFS). Hazard ratios (HRs), 95% confidence intervals (CI), and p-values were calculated using Cox proportional hazards regression analysis after grouped the breast cancer patients by the median of gene level.