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. 2014 Oct 30;7(1):199–211. doi: 10.4161/19420862.2014.979081

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© Chien-Hsing Chang, Yang Wang, Pankaj Gupta, and David M Goldenberg

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Cytotoxicity of epratuzumab in various formats to Daudi cells. (A) Epratuzumab presented as the Dried-I (hLL2*) or Wet-III (hLL2 + GAH + anti-IgM) format (right panel), but not the Wet-I (hLL2) or Wet-IIB (hLL2 + GAH) format (left panel), induced dose-dependent cytotoxicity in Daudi cells, as measured by the MTS assay. (B) The Dried-I format of epratuzumab (hLL2*) induced apoptosis comparable to the positive control (anti-IgM) as determined by the Annexin V assay. (C) The Dried-I format (hLL2*) and the Dried-II format (hLL2 + HUV-EC), in which soluble epratuzumab was added to a monolayer of HUV-EC, induced apoptosis in Daudi cells to a similar extent (∼50%).