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. 2014 Oct 30;7(1):199–211. doi: 10.4161/19420862.2014.979081

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© Chien-Hsing Chang, Yang Wang, Pankaj Gupta, and David M Goldenberg

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 4. — Translocation of CD79a, CD79b, and CD22 to the lipid rafts. (A) left panel, CD22 was detected in the lipid rafts (fractions 3–6) following treatment of D1–1 cells with anti-IgM (10 μg/mL) and both the Wet-I (hLL2, 20 μg/mL) and Dried-I (hLL2*, 20 μg/mL) formats of epratuzumab; right panel, CD79b was translocated to the lipid rafts (fractions 4–7) by either anti-IgM (10 μg/mL) or the Dried-I format of epratuzumab (hLL2*, 20 μg/mL), but not soluble epratuzumab (hLL2). (B) Anti-IgM (lane 6) and epratuzumab of the Dried-I (lane 3) or Wet-III (lane 4) format, but not the Wet-I (lane 2) or Wet-IIA (lane 5) format, induced redistribution of CD22, CD79a, and CD79b to the lipid rafts.