Figure 2.

PET-16 induces proteotoxic stress in MM cells. MM cells were treated with PET-16 (3 μM) for 24h. Cells were then collected and protein lysates were prepared. Detergent soluble and insoluble fractions were resolved on a 10% acrylamide gel. Ubiquitinated protein levels were detected by Western blotting. The results depicted are representative of multiple independent experiments.