Figure 1.

Human identity of camelid IGVH germline families and their corresponding members. Similarity of each of the camelid germline families to their human counterparts is represented by a set of alignments based on the canonical folds of CDR1-2 and the % identity of their corresponding frameworks (FRs). The percentage of identity (%Identity) corresponds to identical amino acids of the V gene framework families (FR1+FR2+FR3) shared by each of the Camelus ferus (camel), Lama pacos (alpaca) and Lama glama (llama) with human IGV reference counterparts (Ref). The % identity is illustrated only for potentially functional genes. Canonical folds of CDR1-2 are indicated between parentheses. Hallmark residues in the FR2 of VHH3 that distinguish them from VH3 are underlined. Also cDNA derived IGHV5 and 7 were depicted with shading on key residues to distinguish them from one another. Complete alignments of all the VH families are illustrated in Figure S1. Stop codons are indicated by a star (*), missing or incomplete amino acid sequences are indicated by a space, and out of frame parts of V gene sequences are indicated by a dash (−).