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. 2015 May 27;7(4):693–706. doi: 10.1080/19420862.2015.1046648

Figure 4.

Figure 4.

Crystal structures of heavy chain and light chain Lama glama V domains (colors) and their human counterparts (gray) depicted as an overlay. Structures are depicted as ribbons, with arrow shapes for the β-strands. (A) The llama anti-CD70 VH (yellow core, red H1 and H2, orange CDR3) is superimposed to its human counterpart (1MFA, all gray). (B) The llama anti-CD70 VL (pink core, green H1-H3) is superimposed to its human counterpart (all gray). (C) Superimposed structures of VH of llama anti-MET mAb (green core, blue H1-H2, red CDR3) onto human heavy chain references 1FVD (Vκ1) and 1HIL (Vκ4) (all gray). (D) Superimposed structures of VK of llama anti-MET mAb (green core, blue H1-H3) onto human heavy chain references 1HIL (Vκ4) (all gray).