Table 1.

Main features of studies included in the meta-analysis

					RET Fusion Positive								Gender		Age			Smoking		Histology		TNM Stage
													M	F	≥60		<60	Y	N	ADC	NADC	I+II	III+IV
Author	Year	Nation	Cases	Age	Total		K		C	N		T	P/N	P/N	P/N		P/N	P/N	P/N	P/N	P/N	P/N	P/N
Takeuchi	2012	Japan	1529	NA	14		12		2	0		0	4/880	10/632		NA	NA	3/995	11/517	14/1108	0/407	1/116	3/387
Yokota	2012	Japan	371	NA	3		3		0	0		0	0/160	3/107		NA	NA	0/90	3/177	3/267	0/101	2/210	1/57
Suechara	2012	USA	69	67.8	1		1		0	0		0	0/29	1/39		1/55	0/13	0/64	1/4	1/68	0/0	NA	NA
Wang	2012	Chinese	936	59.7	13		9		3	1		0	4/288	7/334		3/299	8/323	2/223	9/399	11/622	2/301	5/383	6/239
Kohno	2012	J,U,N*	433	62.3	7		7		0	0		0	4/215	3/211		NA	NA	1/265	6/158	7/426	0/0	NA	NA
Cai	2013	Chinese	392	60	6		6		0	0		0	3/208	3/178		NA	NA	0/148	6/238	4/227	2/159	3/222	3/164
Soo Yoo	2013	Korean	156	63.8	3		2		1	0		0	0/105	3/48		NA	NA	0/102	3/51	3/101	0/52	NA	NA
Tsuta	2014	Japan	1874	63.1	22		19		3	0		0	11/1054	11/798		NA	NA	7/1000	15/852	22/1598	0/254	16/1480	6/358
Pan	2014	Chinese	1139	59.4	15		—	—		—		—	5/507	10/617		4/522	11/602	3/365	12/759	15/1124	0/0	NA	NA

Abbreviations: Age, median age; K,KIF5B-RET; C,CCDC6-RET; N,NCOA4-RET; T,TRIM33-RET; P/N, positive expression/negative expression; M, male; F, female; Y, smoker; N, non-smoker; ADC, adenocarcinoma; NADC, non-adenocarcinoma NSCLC; NA, not available or not applicable; RT-PCR,real-time polymerase chain reaction; FISH, fluorescent in situ hybridization; J,U,N, Japan, USA, Norway.