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. 2014 Oct 30;6(5):1290–1299. doi: 10.4161/mabs.29758

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

© Thilipan Thaventhiran, Naif Alhumeed, Han XA Yeang, Swaminathan Sethu, Jocelyn S Downey, Ahmad F Alghanem, Adedamola Olayanju, Emma L Smith, Michael J Cross, Steven D Webb, Dominic P Williams, Adrian Bristow, Christina Ball, Richard Stebbings, and Jean G Sathish

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Enhanced cell surface expression of LFA-1 and CCR5 on CD28SA-activated CD4⁺ effector memory T cells. Human CD4⁺ T_EMs were stimulated for 1 to 4 d with plate-bound anti-CD3 mAb (CD3, 5 μg/ml); NIB1412 (NIB1412, 10 μg/ml); anti-CD3 mAb and NIB1412 (CD3&NIB1412); control category included cells without any treatment (Control). Cells were harvested at indicated time points and stained with fluorochrome-conjugated anti-CD4 and anti-LFA (A) or anti-CD4 and anti-CCR5 (B) antibodies followed by flow cytometric analysis. (A) Population of CD4⁺LFA⁺ cells are shown in the upper right quadrant as percentages of total T cells. The cells are shown as percentages of total T cells in the upper right quadrant. (B) Population of CD4⁺CCR5⁺ cells are shown in the upper right quadrant as percentages of total T cells. Results are representative of four independent experiments.