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. 2015 Feb 13;16(3):438–449. doi: 10.1080/15384047.2014.1003005

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

© Jessica D Sun, Qian Liu, Dharmendra Ahluwalia, Wenwu Li, Fanying Meng, Yan Wang, Deepthi Bhupathi, Ayesha S Ruprell, and Charles P Hart

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — Antitumor efficacy of TH-302 (T) in combination with gemcitabine (G) and nab-paclitaxel (nP) in 4 PDAC xenograft models: Hs766t (A and B), MIA PaCa-2 (C and D), PANC-1 (E and F) and BxPC-3 (G and H), n = 10 for each group. T was given at 50 mg/kg, ip, G was given at 60 mg/kg ip and nP was given at 30 mg/kg, iv; all drugs were dosed at a Q3Dx5 regimen. A, C, E, and G, tumor growth was monitored and quantified twice a week. Data represent Mean ± SEM. B, D, F and H, Kaplan-Meier analysis plot using tumor size of 1000 mm³ as end-point. V, vehicle; Arrow, dosing time.