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Effect of TH-302 (T) in combination with gemcitabine (G) and nab-paclitaxel (nP) on mechanical hyperalgesia, analyzed by von Frey Assay. T was given at 50 mg/kg, ip, G was given at 60 mg/kg ip and nP was given at 30 mg/kg, iv; all drugs were dosed at a Q3Dx5 regimen. Data represent Mean ± SEM of 10 male CD-1 mice each group. Arrow, dosing time.
