Skip to main content
. 2015 Feb 13;16(3):438–449. doi: 10.1080/15384047.2014.1003005

Figure 5.

Figure 5.

Effect of TH-302 (T) in combination with gemcitabine (G) and nab-paclitaxel (nP) on tumor cells. PANC-1 tumor bearing animals received T, 50 mg/kg, ip; G, 60 mg/kg ip; and nP 30 mg/kg, iv, at a Q3Dx5 regimen. Tumors were collected 24 hrs after the last treatment. (A), representative images of Masson's Trichrome histology staining, TUNEL staining, Caspase-3, γH2AX, and Ki67 immunostaining in vehicle (V), T alone, G + nP doublet and G + nP + T triplet groups. Morphometric analysis of (B), necrotic fraction in the whole tumor by Masson's Trichrome; (C), number of TUNEL-positive apoptotic cells; (D), percentage of Caspase-3 positive apoptotic cells; (E), number of γH2AX positive DNA damage cells; and (F) number of Ki67 positive proliferative cells. *, P < 0.05 as compared to Vehicle (V). a, P < 0.05 as compared to G + nP; b, P < 0.05 as compared to T alone.