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Multivalent Nanobodies elicit accelerated caspase kinetics. MIA PaCa-2 cells were treated with 0.1 nM (left panels) or 1 nM (right panels) of APO2L/TRAIL, DR5Nb1-tri, -tetra or –penta for the indicated times and assessed for caspase-8 (A) or caspase-3/7 (B) using CaspaseGlo-8 or CaspaseGlo-3/7 (Promega), respectively.
