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DR5Nb1-tetra elicits anti-tumor response in the absence of immune cell mediated crosslinking. Mean tumor volume of MIA PaCa-2 tumors in xenograft bearing NSG mice with (dotted line) or without (solid line) TAM depletion (NVP-BLZ945 250 mg/kg po qd) were treated with PBS (10 mL/kg i.v. 1/week), DR5-A (10 mg/kg i.v. 3x/week) or DR5Nb1-tetra (10 mg/kg i.v. 1×/week).
