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The structures of SB transposon and transposase. (A) The transposon has a desired genetic cargo, which is flanked by terminal inverted repeats (IR/DRs, 2 big arrows), each containing 2 binding sites for the transposase. (B) SB transposase has an N-terminal, bipartite, paired-like DNA-binding domain [PAI (Pro, Ala, Ile), RED (Arg, Glu, Asp)] containing a nuclear localization signal (NLS); and C-terminal, which has the DDE (Asp, Asp, Glu) catalytic domain.
