Table 3:

Representative DMRs associated with individual cytogenetic risk groups of AML

			DMR location
				Relative to gene2
Cytogenetic Risk Association1	Related Genes	Gene Descriptions	Relative to CGI	<10kb upstream of TSS	<2kb upstream of TSS	5'UTR	Exon	Intron	3'UTR	<2kb down stream
Low	HOXA7	Homeobox A7	Island
Low	MPDU1	Mannose-P-dolichol utilization defect 1	Shore
Low	AK5	Adenylate kinase 5	Overlap
Low	FAM179B	Family with sequence similarity 179, member B	Island
Low	MEIS1	Meis homeobox 1	NA
Low	HNRPF	Heterogeneous nuclear ribonucleoprotein F	Overlap
Low	TRIM71	Tripartite motif containing 71	Overlap
Low	CD68	CD68 molecule	Shore
Low	BAHCC1	BAH domain and coiled-coil containing 1	Overlap
Low	MN1	Meningioma 1	NA
Mid	NKX2-3	NK2 homeobox 3	Island
Mid	LRAT	Lecithin retinol acyltransferase	Overlap
Mid	C4orf45	Chromosome 4 open reading frame 45	Shore
Mid	FOXB2	Forkhead box B2	Shore
Mid	NXPH2	Neurexophilin 2	Island
Mid	HOXB4	Homeobox B4	Shore
Mid	SNAP25	Synaptosomal-associated protein, 25kDa	Island
Mid	IRX6	Iroquois homeobox 6	Island
Mid	NBEA	Neurobeachin	Island
Mid	HOXB3	Homeobox B3	NA
High	TOB2P1	Transducer of ERBB2, 2 pseudogene 1	Island
High	POU4F1	POU domain, class 4, transcription factor 1	Shore
High	FOXC1	Forkhead box C1	Island
High	DCC	Deleted in colorectal carcinoma	Shore
High	PCDH10	Protocadherin 10 isoform 1 precursor	Shore
High	PDGFRA	Platelet-derived growth factor receptor alpha	Shore
High	MARCKS	Myristoylated alanine-rich protein kinase C	Shore
High	PITX1	Paired-like homeodomain transcription factor 1	Island
High	OTX	Orthodenticle homeobox 1	Island
High	NKX3-2	NK3 homeobox 2	Island

¹Comparison with other AML risk groups; only 10 representative DMRs for each group are shown

²Regions showing increased and decreased methylation are marked as pink and green, respectively.