Table 1.

Reports on consequences of pre-existing antibodies

Drug	Effect	Reference
abciximab	presence of anti-hinge antibodies might be correlated with thrombocytopenia	2, 86, 87
cetuximab	IgE antibodies recognizing alpha-gal sugar moieties caused anaphylactic reactions in patients from certain regions in the United states	96
GSK1995057	in vitro and in vivo cytokine release was associated with antibodies recognizing framework regions of the drug (a VH domain) but not the intact antibody	29
rituximab	decreased in vitro complement-dependent cytotoxicity of rituximab was observed in the presence of rheumatoid factor	44