Table 2.

Association between patient characteristics and response to chemotherapy

Characteristics	n	CR, n	PR, n	SD, n	ORR, %	P-value	CBR, %	P-value
Age (years)
≤ 57	208	0	26	153	12.5	0.003	86.1	0.287
> 57	209	1	49	137	23.9		89.5
Gender
Male	302	1	60	205	20.2	0.091	88.1	0.754
Female	115	0	15	85	13.0		87.0
Performance status (PS)
0–1	401	1	74	275	18.7	0.236	87.3	0.140
2	15	0	1	14	6.7		100
TNM stage
IIIA	42	1	11	27	28.6	0.163	92.9	0.530
IIIB	124	0	23	84	18.5		86.3
IV	251	0	41	179	16.3		87.6
Histologic type
Adenocarcinoma	249	0	28	186	11.2	< 0.001	86.0	0.327
Squamous cell	85	1	26	51	31.8		91.8
Smoking status
Yes	236	0	49	156	20.7	0.125	86.7	0.639
No	181	1	26	133	14.9		88.4
Toxicity outcome (hematologic + gastrointestinal toxicities)
grade 0 to 2 toxicity	232	0	34	172	14.7	0.107	88.8	0.411
grade 3 or 4 toxicity	142	0	30	92	21.1		86.0
p53 p.Pro72Arg (rs1042522)
G/G	138	0	24	98	17.4	0.937	88.4	0.283
G/C	196	1	36	138	18.9		89.3
C/C	80	0	15	51	18.8		82.5
MDM2 c.14+309T>G(rs2279744)
G/G	114	1	22	78	20.2	0.225	88.6	0.896
G/T	274	0	44	194	16.1		86.9
T/T	16	0	5	9	31.3		87.5
MDM2 c.-461C>G (rs937282)
C/C	209	1	37	143	18.2	0.681	86.6	0.586
C/G	152	0	27	106	17.8		87.5
G/G	40	0	5	32	12.5		92.5

CR, Complete response; PR, partial response; SD, stable disease; ORR, objective response rate; CBR, clinical benefit rate.