Table 3.

Association of the polymorphisms and grade 3 or 4 toxicity in young patients (age 57 and younger)

Genotype	n	Grade 3 or 4 toxicity n (%)	OR (95%CI)	P-value
Hematologic toxicity
p53 p.Pro72Arg (rs1042522)
G/G	73	20 (27.4)	1
G/C	99	22 (22.2)	0.777 (0.380–1.589)	0.490
C/C	50	17 (34.0)	1.459 (0.652–3.267)	0.358
Allele of C (G/C+C/C)	149	39 (36.2)	0.974 (0.509–1.863)	0.937
MDM2 c.14+309T>G (rs2279744)
G/G	61	8 (13.1)	1
G/T	150	51 (34.0)	3.578 (1.559–8.207)	0.003
T/T	10	1 (10.0)	0.662 (0.073–5.967)	0.713
Allele of T (G/T+T/T)	160	52 (32.5)	3.295 (1.442–7.530)	0.005
MDM2 c.-461C>G (rs937282)
G/G	21	5 (23.8)	1
C/G	78	22 (28.2)	0.788 (0.250–2.483)	0.684
C/C	114	31 (27.2)	0.810 (0.266–2.465)	0.711
Allele of C (C/G+C/C)	192	53 (27.6)	0.801 (0.272–2.359)	0.687
Gastrointestinal toxicity
p53 p.Pro72Arg (rs1042522)
G/G	73	5 (6.8)	1
C/G	99	8 (8.1)	1.207 (0.367–3.970)	0.757
C/C	50	1 (2.0)	0.300 (0.033–2.726)	0.285
Allele of C (G/C+C/C)	149	9 (6.0)	0.910 (0.285–2.911)	0.874
MDM2 c.14+309T>G (rs2279744)
G/G	61	3 (4.9)	1
G/T	150	10 (6.7)	1.618 (0.417–6.273)	0.486
T/T	10	1 (10.0)	2.425 (0.210–28.029)	0.478
Allele of T (G/T+T/T)	160	11 (6.9)	1.674 (0.438–6.395)	0.451
MDM2 c.-461C>G (rs937282)
G/G	21	0 (0.0)	1
C/G	78	7 (9.0)	1.099 (1.025–1.178)	0.340
C/C	114	7 (6.1)	1.065 (1.017–1.117)	0.595
Allele of C (C/G+C/C)	192	14	1.079 (1.037–1.122)	0.370
Overall toxicity
p53 p.Pro72Arg (rs1042522)
G/G	73	23 (31.5)	1
G/C	99	25 (25.3)	0.775 (0.386–1.556)	0.474
C/C	50	18 (36.0)	1.382 (0.618–3.088)	0.431
Allele of C (G/C+C/C)	149	43 (28.9)	0.949 (0.503–1.791)	0.871
MDM2 c.14+309T>G (rs2279744)
G/G	61	11 (18.0)	1
G/T	150	54 (36.0)	2.763 (1.293–5.905)	0.009
T/T	10	2 (20.0)	1.213 (0.216–7.008)	0.815
Allele of T (G/T+T/T)	160	56 (35.0)	2.641 (1.243–5.614)	0.012
MDM2 c.-461C>G (rs937282)
G/G	21	5 (23.8)	1
C/G	78	24 (30.8)	0.759 (0.236–2.441)	0.644
C/C	114	36 (31.6)	0.677 (0.218–2.100)	0.500
Allele of C (C/G+C/C)	192	60 (31.3)	0.709 (0.236–2.134)	0.541

Note: Bold p-values are statistically significant.