Table 5.
Association of the MDM2 haplotype with grade 3 or 4 toxicity in young patients (age 57 and younger)
| Haplotype of MDM2 genea | n | Grade 3 or 4 toxicity n (%) | OR (95%CI) | P-value |
|---|---|---|---|---|
| Hematologic toxicity | ||||
| CG | 258 | 63 (24.4) | 1 | |
| GT | 108 | 29 (26.9) | 1.134 (0.673–1.911) | 0.637 |
| CT | 63 | 24 (38.1) | 1.876 (1.033–3.406) | 0.039 |
| GG | 19 | 4 (21.1) | 0.808 (0.253–2.582) | 0.719 |
| Gastrointestinal toxicity | ||||
| CG | 258 | 16 (6.2) | 1 | |
| GT | 108 | 7 (6.5) | 1.064 (0.418–2.705) | 0.897 |
| CT | 63 | 5 (7.9) | 1.483 (0.510–4.310) | 0.469 |
| GG | 19 | 0 (0) | — | — |
| Overall toxicity | ||||
| CG | 258 | 72 (27.9) | 1 | |
| GT | 108 | 31 (28.7) | 1.051 (0.627–1.763) | 0.850 |
| CT | 63 | 27 (42.9) | 2.109 (1.152–3.860) | 0.016 |
| GG | 19 | 4 (21.1) | 0.665 (0.206–2.148) | 0.495 |
Note: Bold p-values are statistically significant. aHaplotypes were composed of MDM2 c.−461C>G- c.14+309T>G, in order.