Fig. 4.

Tyrosine hydroxylase (TH) and serotonin (5HT) immunostainings. A complete unilateral dopamine depletion following the injection of 6-OHDA in the right medial forebrain bundle (MFB) is represented on micrographs (a–c). The asterisks indicate the tip of the stimulating electrodes placed bilaterally into the MBF (b). MFB-DBS led to an increase in the number of 5HT immunoreactivity in the dorsal raphe nucleus (DRN) (d). Arrows indicate positive staining in the DRN. CPu caudate-putamen (striatum), aca anterior commissure, AcbSH nucleus accumbens, shell, AcbC nucleus accumbens core, 3V third ventricle, Aq aqueduct, Tu olfactory tubercle, PAG periaqueductal gray, VTA ventral tegmental area, SN substantia nigra, DRNv dorsal raphe nucleus, ventral part, DRNd dorsal raphe nucleus, dorsal part, Rf reticular formation