Table 3.
Demographic, clinical and laboratory data in patients with primary hypertension according to eNOS G894T genotype variants
| Variables | GG (1) | GT + TT (2) | GT (2a) | TT (2b) | p |
|---|---|---|---|---|---|
| N | 60 | 66 | 53 | 13 | |
| Birth weight (g) | 3325 (1790–4200 ) | 3400 (1410–5250) | 3300 ( 1410–4000) | 3500 (3140–5250) | 1 vs. 2b p = 0.03 2a vs. 2b p = 0.06 |
| BMI | 24.9 ± 4.4 | 24.8 ± 4.6 | 24.6 ± 4.2 | 25.6 ± 6.3 | ns |
| BMI-SDS | 1.55 (−1.26 to 6.03) | 1.64 (−0.81 to 9.69) | 1.64 (−1.56 to 9.69) | 1.79 (−0.81 to 5.8) | ns |
| WC (cm) | 85.14 ± 10.8 | 81.23 ± 12.9 | 81.23 ± 12.08 | 81.33 ± 16.6 | ns |
| WC-SDS | 1.82 (−0.94 to 4.88) | 1.38(−2.03–6.1) | 1.35(−2.03–6.12) | 1.40 (−1.1 to 4.5) | ns |
| WHR | 0.86 ± 0.07 | 0.83 ± 0.06 | 0.82 ± 0.07 | 0.84 ± 0.07 | 1 vs. 2 p = 0.01 1 vs. 2a p < 0.01 |
| SPBP/24 h (mmHg) | 129 ± 8 | 130 ± 8 | 130 ± 8 | 130 ± 9 | ns |
| SBPi/24 h | 1.02 (0.89–1.17) | 1.02(0.91–1.23) | 1.02 (0.92–1.20) | 1.03 (0.90–1.23) | ns |
| DBP/24 h (mmHg) | 73 ± 6 | 72 ± 8 | 72 ± 7 | 73 ± 9 | ns |
| DBPi/24 h | 0.95 (0.81–1.23) | 0.94 (0.69–1.27) | 0.94 (0.82–1.27) | 0.94 (0.8–1.12) | ns |
| HR/24 h (/min) | 82 ± 10 | 77 ± 12 | 77 ± 12 | 78 ± 10 | 1 vs. 2 p = 0.02 1 vs. 2a p = 0.03 1 vs. 2b p = 0.1 |
| IMT (mm) | 0,43 (0.34–0.52) | 0.44 (0.345–0.62) | 0.43 (0.345–0.62) | 0.465 (0.36–0.57) | 1 vs. 2 p = 0.01 1 vs. 2a p = 0.05 1 vs. 2b p = 0.02 |
| IMT-SDS | 0,86 (−1.05 to 3.12) | 1.03 (−1.37 to 7.2) | 1 (−1.37–7.2) | 1.49 (−0.35 to 2.7) | 1 vs. 2 p = 0.03 1 v.s 2a p = 0.06 1 vs 2b p = 0.03 |
| Albuminuria (mg/24 h) | 13.5 (2–57.6) | 15.2 (4.6–250) | 14.7 (4.6–250) | 16.2 (9.3–54.6) | 1 vs. 2 p = 0.17 |
| LVMi (g/m2.7) | 35.2 ± 8.0 | 36.9 ± 9.4 | 36.6 ± 9.4 | 37.7 ± 9.6 | ns |
| RWT (mm) | 0.32 (0.23–0.59) | 0.36 (0.23–0.59) | 0.35 (0.23–0.59) | 0.36 (0.28–0.45) | 1 vs. 2b p = 0.1 |
| TTG/HDL | 1.87 (0.78–-12.9) | 1.84 (0.58–42.5) | 1.9 (0.58–42.5) | 1.77 (0.78–2.91) | ns |
| hsCRP (mg/l) | 0.76 (0.02–3.98) | 0.69 (0.05–4.68) | 0.84 (0.05–4.68) | 0.41 (0.14–0.82) | 1 vs. 2b p = 0.05 2a vs. 2b p = 0.06 |
| Fasting insulin (mU/ml) | 12.9 (6.4–39) | 12.8 (3–36) | 12.8 (3–36) | 12.9 (6.7–30) | ns |
| HOMA -R | 2.86 (1.26–8.77) | 2.68 (1.1–7.9) | 2.73 (1.1–7.92) | 2.64 (1.38–6.23) | ns |
| HbA1c (%) | 5.4 (4.1–6.8) | 5.3 (4.2–6.6) | 5.3 (4.2–6.6) | 5.0 (4.5-5–6) | 1 vs. 2 p = 0.11 1 vs. 2b p = 0.1 |
| GPx (U/gHb) | 31.6 (28.3–39.9) | 31.4 (23–8-38.1) | 31.3 (23.8–38.1) | 33.2 (30.8–36.9) | 2a vs. 2b p = 0.07 |
| Number of patients with MS | 10 | 12 | 9 | 3 | ns |
Data are presented as the mean ± SD, as the median with the range in parenthesis or as a number, as appropriate
GG G894 homozygotes, GT carriers of G894 and T894 allele, TT T894 homozygotes, WHR waist-to-hip ratio, SBP/24 h mean systolic blood pressure in 24-h ambulatory blood pressure monitoring (ABPM), SBPi/24 h index of SBP/24 h, DBP/24 h mean diastolic systolic blood pressure in 24-h ABPM, DBPi/24 h index of DBP/24 h, HR/24 h mean heart rate in 24-h ABPM, RWT relative wall thickness, HbA1c glycated hemoglobin, MS metabolic syndrome