Table 1.
Characteristics of a 10 mg/ml solution of antibody in PBS pH 7.2 after nebulization with three nebulizers. Each result is the mean (± SD) of three nebulizations
| Nebulizer | Hydrodynamic diameter (nm ± SD) | Percentage monomers (% mass) | Size exclusion chromatography (% monomers/% other aggregates) | VMD (μm) (mean ± SD) | Flow rate (ml/min ± SD) |
|---|---|---|---|---|---|
| Omron | NA | NA | 91.1 ± 0.6 / 8.9 ± 0.5 | 5.6 ± 0.1 | 0.23 ± 0.04 |
| Aerogen Solo | NA | NA | 91.3 ± 2.5 / 8.7 ± 1.9 | 4.1 ± 0.1 | 0.50 ± 0.01 |
| PARI eFlow | NA | NA | 90.6 ± 0.5 / 9.5 ± 0.6 | 3.8 ± 0.3 | 0.45 ± 0.05 |