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. 2015 Oct 28;6:1189. doi: 10.3389/fmicb.2015.01189

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Copyright © 2015 Goolab, Roth, van Heerden and Crampton.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The proposed translocation pathway for the dual topology E. coli Braun’s lipoprotein (Lpp). After generating the mature Lpp (green structure), the lipoprotein in the inner membrane (IM) interacts with the lipoprotein localization machinery (Lol) located in the periplasm. Adenosine triphosphate (ATP) hydrolysis, an ABC transporter (LolCDE), a carrier protein (LolA) and outer membrane (OM) lipoprotein receptor (LolB) mediates the “mouth-to-mouth” the transfer of Lpp from the IM to the OM. Lpp may reside in the periplasm anchored to the inner leaflet of the OM (bound form) or spans the OM resulting in the surface exposure of its C terminus (free form). Abbreviations used: Braun’s lipoprotein (Lpp), inner membrane (IM), lipoprotein localization machinery (Lol), adenosine triphosphate (ATP), outer membrane (OM), ATP binding cassette (ABC).