Table 2.
Target region locations (labels for local maxima and x, y, z coordinates), p-value at the local maxima and cluster size (in voxels) from a group comparison between patients with chronic tinnitus and matched controls, with hearing loss level as a covariate.
| Seed region | Targets : left hemisphere seed | p | Targets: right hemisphere seed | p | Target network |
|---|---|---|---|---|---|
| Area LC | ↑ Left MTG (–58, –12, –13) | 0.00740 | ↑ Right STG (62, 82) | 0.00046 | Auditory |
| ↓ Left lingual gyrus (–17, –59, –8) | 0.00590 | ↓ Left lingual gyrus (–11, –58, –2) ↓ Right lingual gyrus (23, –63, –5) ↑Right MOG (36, –95, 5) |
0.00450 0.00044 0.00680 |
Visual | |
| ↓ Left culmen (–14, –49, –6) | 0.00660 | Cerebellar | |||
| ↑ Right PoCG (44, –39, 52) | 0.00210 | Parietal | |||
| Caudate Head | ↓ Left culmen (–8, –59, –6) | 0.00360 | Cerebellar | ||
| ↑ Right putamen (20, 7, –11) | 0.00126 | Basal Ganglia | |||
| ↓ Right lingual gyrus (24, –65, –8) | 0.00740 | Visual | |||
| ↑ Right MFG (3, 45, 47) | 0.00240 | ↑ Left SFG (–3, 38, 54) | 0.00720 | Dorsal Pre-frontal | |
| ↑ Right cingulate (5, 17, 47) | 0.00520 | Default mode network (DMN) | |||
| ↑ Right IPL (41, –40, 53) | 0.00076 | ↑ Right IPL (42, –38, 51) | 0.00110 | Parietal | |
| Nucleus Accumbens | ↓ Right STG (65, –24, –1) | 0.00600 | ↑ Left MTG (–60, –26, –12) | 0.00650 | Auditory |
| ↑ Left SFG (–4, 52, –21) | 0.00210 | Orbital pre-frontal | |||
| ↓ Rght culmen (10, –55, 6) | 0.00079 | ↑ LeftPoCb (–12, –76, –23) | 0.00400 | Cerebellar | |
| ↓ Left lingual gyrus (–16, –55, 7) ↓ Right lingual gyrus (19, –69, 6) |
0.00220 0.00130 |
↑ Left lingual (–25, –76, –12) | 0.00120 | Visual | |
| ↓ Left IPL (–36, –44, 48) | 0.00630 | ↑ Left I PL (–40, –38, 48) | 0.00420 | Parietal | |
| Primary Auditory Cortex | ↑ Right anterior STG (52, 14, –25) | 0.00740 | Temporal pole | ||
| ↑ Left MTG (–65, –34, –6) | 0.00730 | ↑ Left MTG (–60, –34, –7) | 0.00740 | Auditory | |
| ↑ Left SFG (–6, 56, –21) | 0.00210 | ↑ Left SFG (–6, 55, –21) | 0.00230 | Orbital pre-frontal | |
| ↑ Left PoCb (–11, –79, –21) | 0.00650 | Cerebellar | |||
| ↑ Right PHCG (27, 3, –13) | 0.00210 | Hippocampal | |||
| ↑ Left lingual gyrus (–29, –82, –11) | 0.00330 | ↑ Right MOG (50, –70, –12) | 0.00710 | Visual | |
| ↑ Right PoCG (64, –24, 18) | 0.00730 | Parietal |
Target regions for the four different seed regions (area LC, CH, NA, and A1) are shown for each hemisphere. Target regions are organized by the target network shown in the last column. SFG, superior frontal gyrus; IPL, inferior parietal lobe; MTG, middle temporal gyrus; MOG, middle occipital gyrus; PoCG, post-central gyrus; STG, superior temporal gyrus; MFG, middle frontal gyrus; PHCG, parahippocampal gyrus; PoCb, posterior cerebellum.