Figure 2.

Schematic representation of the Gαq and Gαs pathways that regulate neurotransmitter secretion in C. elegans. Gαq signaling causes increased DAG levels, whereas the Gαs pathway causes increased cAMP levels. C. elegans protein names are shown in uppercase letters and mammalian homolog names are shown in parentheses. The blue box surrounds the Gαq pathway and the red box surrounds the Gαs pathway. Proteins labeled in blue inhibit neurotransmitter release and those in green promote release. Lines ending in arrows are positive regulation; lines ending in balls are negative regulation. Figure modeled after Perez-Mansilla and Nurrish (2009).