Table 25.
Average Annual Age-Adjusted Incidence Ratesa,b of Brain and Central Nervous System Tumors by Major Histology Groupings, Histology and NCI Age Groups, CBTRUS Statistical Report: NPCR and SEER, 2008-2012
| Histology | Age at Diagnosis (years) |
|||||
|---|---|---|---|---|---|---|
| Childrenc (0-14) |
AYAd (15-39 ) |
Adults (40+) |
||||
| Rate | (95% CI) | Rate | (95% CI) | Rate | (95% CI) | |
| Tumors of Neuroepithelial Tissue | 4.00 | (3.93-4.07) | 3.45 | (3.40-3.50) | 10.54 | (10.46-10.62) |
| Pilocytic astrocytoma | 0.97 | (0.93-1.00) | 0.28 | (0.27-0.30) | 0.08 | (0.08-0.09) |
| Diffuse astrocytoma | 0.27 | (0.25-0.28) | 0.47 | (0.45-0.49) | 0.72 | (0.70-0.74) |
| Anaplastic astrocytoma | 0.08 | (0.07-0.09) | 0.27 | (0.26-0.29) | 0.61 | (0.59-0.62) |
| Unique astrocytoma variants | 0.10 | (0.09-0.11) | 0.07 | (0.06-0.08) | 0.05 | (0.04-0.05) |
| Glioblastoma | 0.15 | (0.13-0.16) | 0.48 | (0.46-0.5) | 6.96 | (6.90-7.02) |
| Oligodendroglioma | 0.04 | (0.03-0.05) | 0.29 | (0.28-0.31) | 0.33 | (0.31-0.34) |
| Anaplastic oligodendroglioma | – | – | 0.08 | (0.08-0.09) | 0.17 | (0.16-0.18) |
| Oligoastrocytic tumors | 0.02 | (0.02-0.03) | 0.26 | (0.25-0.28) | 0.25 | (0.24-0.26) |
| Ependymal tumors | 0.30 | (0.28-0.32) | 0.37 | (0.35-0.38) | 0.54 | (0.53-0.56) |
| Glioma malignant, NOS | 0.77 | (0.74-0.80) | 0.27 | (0.25-0.28) | 0.48 | (0.47-0.50) |
| Choroid plexus tumors | 0.12 | (0.10-0.13) | 0.04 | (0.03-0.04) | 0.04 | (0.03-0.04) |
| Other neuroepithelial tumors | 0.01 | (0.01-0.01) | 0.01 | (0.00-0.01) | 0.01 | (0.00-0.01) |
| Neuronal and mixed neuronal-glial tumors | 0.35 | (0.33-0.37) | 0.34 | (0.32-0.35) | 0.21 | (0.20-0.22) |
| Tumors of the pineal region | 0.05 | (0.04-0.05) | 0.05 | (0.04-0.06) | 0.04 | (0.03-0.04) |
| Embryonal tumors | 0.78 | (0.75-0.81) | 0.17 | (0.16-0.18) | 0.07 | (0.06-0.07) |
| Tumors of Cranial and Spinal Nerves | 0.26 | (0.24-0.28) | 0.91 | (0.88-0.94) | 3.22 | (3.18-3.26) |
| Nerve sheath tumors | 0.26 | (0.24-0.28) | 0.91 | (0.88-0.94) | 3.21 | (3.17-3.26) |
| Other tumors of cranial and spinal nerves | – | – | – | – | 0.00 | (0.00-0.00) |
| Tumors of Meninges | 0.16 | (0.15-0.17) | 1.99 | (1.95-2.03) | 17.18 | (17.08-17.27) |
| Meningioma | 0.09 | (0.08-0.10) | 1.74 | (1.71-1.78) | 16.77 | (16.68-16.87) |
| Mesenchymal tumors | 0.05 | (0.04-0.06) | 0.07 | (0.06-0.07) | 0.11 | (0.11-0.12) |
| Primary melanocytic lesions | – | – | 0.00 | (0.00-0.01) | 0.02 | (0.01-0.02) |
| Other neoplasms related to the meninges | 0.02 | (0.01-0.02) | 0.18 | (0.17-0.19) | 0.27 | (0.26-0.29) |
| Lymphomas and Hematopoietic Neoplasms | 0.03 | (0.02-0.03) | 0.12 | (0.12-0.14) | 0.94 | (0.92-0.97) |
| Lymphoma | 0.01 | (0.01-0.01) | 0.12 | (0.11-0.13) | 0.93 | (0.90-0.95) |
| Other hematopoietic neoplasms | 0.02 | (0.01-0.02) | 0.01 | (0.01-0.01) | 0.02 | (0.02-0.02) |
| Germ Cell Tumors and Cysts | 0.20 | (0.18-0.21) | 0.12 | (0.11-0.13) | 0.03 | (0.03-0.04) |
| Germ cell tumors, cysts and heterotopias | 0.20 | (0.18-0.21) | 0.12 | (0.11-0.13) | 0.03 | (0.03-0.04) |
| Tumors of Sellar Region | 0.44 | (0.42-0.46) | 3.24 | (3.19-3.29) | 5.65 | (5.60-5.71) |
| Tumors of the pituitary | 0.22 | (0.21-0.24) | 3.11 | (3.06-3.16) | 5.44 | (5.38-5.49) |
| Craniopharyngioma | 0.22 | (0.20-0.23) | 0.13 | (0.12-0.14) | 0.21 | (0.20-0.22) |
| Unclassified Tumors | 0.28 | (0.26-0.30) | 0.63 | (0.61-0.65) | 2.19 | (2.16-2.23) |
| Hemangioma | 0.09 | (0.08-0.10) | 0.30 | (0.29-0.32) | 0.50 | (0.48-0.52) |
| Neoplasm, unspecified | 0.18 | (0.17-0.20) | 0.32 | (0.31-0.34) | 1.69 | (1.66-1.72) |
| All other | 0.01 | (0.00-0.01) | – | – | 0.01 | (0.01-0.01) |
| TOTALe | 5.37 | (5.28-5.45) | 10.47 | (10.38-10.56) | 39.75 | (39.61-39.9) |
aRates are per 100,000 and age-adjusted to the 2000 US. standard population.
bChildren as defined by the National Cancer Institute, see: http://www.cancer.gov/researchandfunding/snapshots/pediatric.
cAdolescents and Young Adults (AYA), as defined by the National Cancer Institute, see: http://www.cancer.gov/researchandfunding/snapshots/adolescent-young-adult.
dRefers to all brain tumors including histologies not presented in this table.
eSource: Estimation based on CBTRUS NPCR and SEER 2006-2012 data.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific histology category. The suppressed cases are included in the counts and rates for totals.
*Estimated number is less than 50 and may affect totals.
Abbreviations: AYA, Adolescents and Young Adults, CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology and End Results program; CI, confidence interval; NOS, not otherwise specified.