Table 2.

Differential DNA methylation for single CpG sites and nicotine exposure for lung samples (P< 0.01)

NAME	CHR	Gene Symbol	logFC	P-value*	Mean -value in controls#	Mean in nicotine exposed#	logFC Age adjusted	P-value Age adjusted
cg23361828	2		−0.07	1.76E−03	0.61	0.54	−0.06	3.18E−03
cg17165241	11	PKP3	0.10	2.94E−03	0.63	0.72	0.09	3.71E−03
cg25612428	5	ANKRD33B	−0.07	3.12E−03	0.32	0.25	−0.07	5.42E−03
cg20142762	19	NCR1	0.07	3.67E−03	0.39	0.46	0.07	3.32E−03
cg19605788	19	CNTD2	0.06	4.90E−03	0.32	0.38	0.06	3.55E−03
cg20905796	11		0.09	4.93E−03	0.27	0.36	0.10	2.72E−03
cg22670147	2	DPP10	−0.06	5.43E−03	0.18	0.11	−0.07	3.14E−03
cg15864601	17	C17orf97	−0.07	5.91E−03	0.24	0.17	−0.07	3.45E−03
cg14223671	16	PRR25	−0.06	6.65E−03	0.29	0.22	−0.07	4.34E−03
cg07509935	14	LTB4R2; CIDEB; LTB4R	−0.08	6.71E−03	0.23	0.15	−0.08	9.07E−03
cg27055313	14		0.08	7.14E−03	0.34	0.42	0.08	1.19E−02
cg08537890	12		0.08	7.43E−03	0.43	0.51	0.08	9.41E−03
cg02407415	16	PRR25	−0.09	7.76E−03	0.33	0.24	−0.09	5.74E−03
cg06531573	16	PRR25	−0.08	8.04E−03	0.33	0.25	−0.08	5.68E−03
cg19430537	17		−0.10	9.13E−03	0.51	0.41	−0.08	2.38E−02
cg07234876	8		0.10	9.20E−03	0.71	0.81	0.10	1.76E−02

^# Mean β-values are the raw means in nicotine exposed and unexposed (control) tissue.

^* P-values for nicotine exposure coefficient from the limma model.

logFC: log fold change obtained from the limma model.