Table 4.
Overlapping CpG sites in the lung and placental analyses
| NAME | CHR | Gene Symbol | Difference in mean -values: Lung (exposed-unexposed)# | Difference in mean -values: Placenta (exposed-unexposed)# |
|---|---|---|---|---|
| cg12036633 | 15 | 0.16 | 0.15 | |
| cg21442271 | 22 | 0.11 | 0.09 | |
| cg11478607 | 22 | GSTT1 | 0.10 | 0.08 |
| cg16875032 | 8 | SNTB1 | 0.06 | 0.08 |
| cg08801017 | 13 | LOC100101938 | 0.05 | 0.07 |
| cg10909185 | 11 | KLHL35 | 0.08 | 0.07 |
| cg05353869 | 11 | KLHL35 | 0.07 | 0.06 |
| cg27055313 | 14 | 0.08 | 0.06 | |
| cg10546252 | 22 | GSTT1 | 0.09 | 0.06 |
| cg05840289 | 5 | ANKRD33B | 0.06 | 0.06 |
| cg02405213 | 9 | JAK2 | 0.06 | 0.06 |
| cg08537890 | 12 | 0.08 | 0.05 | |
| cg19596870 | 6 | SERPINB6 | 0.09 | 0.05 |
| cg08845336 | 6 | HLA-DRB1 | −0.08 | −0.06 |
| cg03749207 | 16 | PRR25 | −0.08 | −0.06 |
| cg06531573 | 16 | PRR25 | −0.08 | −0.06 |
| cg01826367 | 1 | −0.05 | −0.07 | |
| cg02407415 | 16 | PRR25 | −0.09 | −0.09 |
| cg18433519 | 6 | KIAA0319 | −0.10 | −0.11 |
# Mean β-values are the raw means in nicotine exposed and control tissue.
Sites listed were found to be significant at a nominal P-value of 0.05, in both lung and placental tissue analysis, after removal of sites with SNPs or apparent SNP effects.