Table 4.
Summary of the challenging tumours
| Case & Initial diagnosis | Malignancy criteria | p16 (% & score) | Ki-67 (% & score) | HMB45 gradient (& score) | p16-Ki-67 score | p16-Ki67-HMB45 score |
|---|---|---|---|---|---|---|
| Case #1: Cellular blue nevus, leg, 14 year-old boy | FISH : chromosome 6 polysomy, 8p34 gain, 9p21 double deletion, 11q13.1 gain | 15 % (score 1) | 3 % (score 1) | Absent (score 2) | Score 2 | Score 4 |
| Case #2: Spitz nevus, back, 42 year-old woman | FISH: chromosomes 6 and 8 polysomies, 9p21 double deletion, 11q13.1 gain | 0 % (score 3) | 12 % (score 3) | Absent (score 2) | Score 6 | Score 8 |
| Case #3: SSM on preexisting nevus, back, 59 year-old man | Clear SSM features | Whole lesion : 70 % (score 0) Atypical component : 0 % (score 3) | 10 % (score 2) | Doubtful (score 1) | Whole lesion: score 3 SSM: score 6 | Whole lesion: score 2 SSM: score 5 |
| Case #4: SSM on preexisting nevus, ear, 64 year-old man | Clear SSM features | Whole lesion : 70 % (score 0) Atypical component : 0 % (score 3) | 10 % (score 2) | Doubtful (score 1) | Whole lesion: score 3 SSM: score 6 | Whole lesion: score 2 SSM: score 5 |
| Case #5: Nevus, back, 41 year-old man | Metastatic evolution : reclassed as SSM | 80 % (score 0) | 20 % (score 3) | Absent (score 2) | Score 3 | Score 5 |
| Case #6: Nevus, back, 39 year-old woman | Metastatic evolution : reclassed as nevoid melanoma | 5 % (score 2) | 8 % (score 2) | Inconclusive (score 1) | Score 4 | Score 5 |
| Case #7: Atypical nevus, knee, 43 year-old man | Metastatic evolution : reclassed as nodular melanoma | 0 % (score 3) | 16 % (score 3) | Present (score 0) | Score 6 | Score 6 |
| Case #8: Spitz nevus, thigh, 24 year-old man | Metastatic evolution : reclassed as Spitzoid melanoma | 0 % (score 3) | 12 % (score 3) | Absent (score 2) | Score 6 | Score 8 |
| Case #9: Nevoid melanoma, 17-year old girl, calf | Concomitant metastasis | 20 % (score 1) | 12 % (score 3) | Absent (score 2) | Score 4 | Score 6 |
| aCase #10: Spitzoid tumour, knee, 17-year old girl, knee | Review by an international expert in melanocytic pathology, reclassed as Spitzoid melanoma | 15 % (score 1) | 25 % (score 4) | Inconclusive (score 1) | Score 5 | Score 6 |
| aCase #11: SSM, back, 58-year old woman | No final histological criteria of malignancy, reclassed as a compound nevus | 60 % (score 0) | 1 % (score 0) | Inconclusive (score 1) | Score 0 | Score 1 |
SSM superficial spreading melanoma
acases from the validation set