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. Author manuscript; available in PMC: 2016 Sep 3.
Published in final edited form as: J Phys Chem B. 2015 Aug 14;119(35):11513–11526. doi: 10.1021/acs.jpcb.5b05467

Table 1.

The rate coefficients for the transition between open to closed states (k2 and k−2) computed by Milestoning. The experimental results are provided in parentheses when available.

Substrate k2(s−1) k−2(s−1)
Correct 2500–20000 (2000) 40 (3)
Mismatch 200–400 (>500) 4000 (>1200)
No-Nucleotide 100–2000 40000
After Chemistry 8×10^6 4400