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. 2015 Feb 5;7(2):344–351. doi: 10.1080/19420862.2015.1008345

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© The Jackson Laboratory

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — Description of albumin mutations and MSA levels. (A) TALEN targeted region of albumin exon 4, DNA and predicted amino acid sequences. Dashes indicate deleted base(s) in the mutant allele and the amino acids in gray illustrate the predicted change from wild type sequence due to the frame shift. In B6-Alb^-/-, TALEN-mediated deletion causes a frame shift leading to a premature stop codon 55 amino acids downstream (not shown). In Tg32-Alb^-/- the mutation leads to a frame shift and a stop codon 5 amino acids downstream (boxed*). (B) Mouse albumin concentrations in serum. For each group, 4 males and 4 females were analyzed. MSA concentrations of mice for Alb-null homozygotes were below the detection limit of the ELISA (0.2 g/L).