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Variants selected using phage display
| VL-residue |
VH-residue |
Phage IC50 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant | 28 | 30 | 32 | 91 | 96 | 98 | 99 | 100a | 100c | GT1a | GT1b |
| WT | Y | I | F | S | Y | Y | Y | K | Y | 1 | 1 |
| HA1 | W | L | F | S | Y | Y | Y | I | Y | 20 | 4 |
| HA2 | Y | F | F | S | Y | Y | F | P | Y | 6 | 2 |
| HA3 | W | A | F | S | Y | Y | Y | P | Y | 2 | 8 |
| HA4 | F | L | F | S | Y | Y | Y | H | Y | 3 | 10 |
| HA5 | Y | V | F | S | Y | Y | Y | T | Y | 3 | 10 |
| HA6 | W | I | F | S | Y | F | Y | E | Y | 6 | 5 |
| HA7 | F | I | F | S | Y | F | Y | P | F | 2 | 2 |
Phage IC50 are shown as fold decrease relative to WT.
