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. 2014 Nov 7;9(10):1366–1373. doi: 10.4161/15592294.2014.969625

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Figure 3. — HLA-DRB1 and HLA-DQB1 methylation levels in Kazakh ESCC, ACN, and NE samples. (A) Overall methylation level of HLA-DRB1 in Kazakh ESCC, ACN, and NE samples. The overall methylation level of NE is significantly higher than that of ESCC and ACN (both P < 0.05). (B) Methylation levels of different CpG units of HLA-DRB1 contrast in Kazakh ESCC, ACN, and NE samples. 3 CpG (CpG9, 10-11, and 16) units exhibited significantly decreased methylation levels in ESCC compared to NE samples (all P < 0.05). Methylation levels of 2 CpG units (10-11 and 16) are significantly lower in ESCC than in ACN samples (all P < 0.05). The methylation levels of 2 CpG units (9 and 10-11) are significantly decreased in ESCC compared to ACN levels (all P < 0.05). (C) Overall methylation levels of HLA-DQB1 in Kazakh ESCC, ACN, and NE samples. The overall methylation level in ESCC is significantly higher than that in ACN and NE (all P < 0.05). (D) Methylation levels of different CpG units of HLA-DQB1 in Kazakh ESCC, ACN, and NE samples. Methylation levels of 2 CpG units (CpG6-7 and 16-17) are significantly increased in ESCC compared to that in NE samples (all P < 0.05).