Table 2.
The hazard ratios for developmental milestones (in months) and risk of schizophrenia in groups with and without parental psychosis and in the total study sample.
| Schizophrenia | Total |
Parental psychosis |
No parental psychosis |
Interaction |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | HR (95% CI) | n | Mean (SD) | HR (95% CI) | n | Mean (SD) | HR (95% CI) | HR (95% CI) | ||
| Holding the head up | No | 2.13 (0.74) | Ref. | 282 | 2.21 (0.71) | Ref. | 5241 | 2.13 (0.74) | Ref. | Ref. |
| Yes | 2.22 (0.78) | 1.17 (0.89–1.54) | 10 | 2.70 (0.68) | 2.46 (1.07–5.66) | 77 | 2.16 (0.78) | 1.06 (0.78–1.42) | 2.38 (0.98–5.79) | |
| Gripping an object | No | 3.24 (0.69) | Ref. | 278 | 3.33 (0.68) | Ref. | 5014 | 3.23 (0.69) | Ref. | Ref. |
| Yes | 3.24 (0.59) | 1.02 (0.75–1.38) | 12 | 3.25 (0.45) | 0.85 (0.36–2.02) | 74 | 3.24 (0.62) | 1.02 (0.74–1.42) | 0.84 (0.34–2.10) | |
| Turning from back to tummy | No | 4.36 (1.10) | Ref. | 315 | 4.35 (1.19) | Ref. | 5639 | 4.36 (1.10) | Ref. | Ref. |
| Yes | 4.52 (1.00) | 1.13 (0.95–1.35) | 13 | 4.38 (1.12) | 1.02 (0.67–1.56) | 77 | 4.55 (0.99) | 1.16 (0.96–1.40) | 0.88 (0.55–1.40) | |
| Sitting without support | No | 7.22 (1.16) | Ref. | 266 | 7.33 (1.65) | Ref. | 5006 | 7.22 (1.13) | Ref. | Ref. |
| Yes | 7.32 (1.21) | 1.06 (0.89–1.27) | 13 | 7.31 (1.49) | 0.99 (0.71–1.38) | 65 | 7.32 (1.16) | 1.08 (0.87–1.33) | 0.92 (0.62–1.35) | |
| Touching the thumb with the index finger | No | 7.40 (1.31) | Ref. | 167 | 7.49 (1.20) | Ref. | 3132 | 7.40 (1.32) | Ref. | Ref. |
| Yes | 7.64 (1.45) | 1.15 (0.93–1.42) | 7 | 8.57 (1.40) | 1.84 (1.11–3.06) | 43 | 7.49 (1.42) | 1.05 (0.84–1.32) | 1.76 (1.01–3.05) | |
| Standing up | No | 8.44 (1.41) | Ref. | 277 | 8.56 (1.87) | Ref. | 4991 | 8.43 (1.38) | Ref. | Ref. |
| Yes | 8.75 (1.45) | 1.14 (1.01–1.28) | 15 | 8.87 (1.60) | 1.05 (0.87–1.27) | 66 | 8.73 (1.42) | 1.16 (0.99–1.37) | 0.90 (0.70–1.16) | |
| Standing without support | No | 10.40 (1.35) | Ref. | 422 | 10.46 (1.46) | Ref. | 7805 | 10.40 (1.34) | Ref. | Ref. |
| Yes | 10.80 (1.36) | 1.22 (1.08–1.37) | 18 | 10.94 (1.16) | 1.17 (0.93–1.48) | 100 | 10.77 (1.40) | 1.21 (1.06–1.39) | 0.97 (0.74–1.27) | |
| Walking without support | No | 11.47 (1.54) | Ref. | 418 | 11.70 (2.13) | Ref. | 7370 | 11.46 (1.50) | Ref. | Ref. |
| Yes | 12.13 (1.92) | 1.15 (1.09–1.21) | 18 | 12.67 (2.30) | 1.08 (0.99–1.18) | 89 | 12.02 (1.83) | 1.22 (1.10–1.37) | 0.88 (0.76–1.01) | |
| Principal component score | No | 0.00 (1.00) | Ref. | 107 | 0.13 (1.04) | Ref. | 2143 | −0.01 (0.99) | Ref. | Ref. |
| Yes | 0.31 (0.84) | 1.33 (0.98–1.80) | 5 | 0.63 (0.41) | 1.48 (0.70–3.13) | 30 | 0.26 (0.89) | 1.28 (0.92–1.79) | 1.16 (0.52–2.62) | |
SD: standard deviation; HR: hazard ratios for one-month delay, adjusted for gender.