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. 2015 Sep 14;1(1):e000153. doi: 10.1136/rmdopen-2015-000153

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

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Factors influencing the relationship between disease activity (as measured with the ASDAS) and radiographic progression (as measured with the 2-year mSASSS progression) and possible relationships between them (A) hypothesis 1: occupational activity modifies the relationship between disease activity and radiographic progression and this effect might be confounded by the effect of gender, smoking status and/or low socioeconomic status, which can, for example, be measured with education, personal income, family income. (B) Hypothesis 2: smoking status modifies the relationship between disease activity and radiographic progression and this effect might be confounded by the effect of gender, occupational activity and/or low socioeconomic status. ASDAS, Ankylosing Spondylitis Disease Activity Score; mSASSS, modified Stoke Ankylosing Spondylitis Spine Score.