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(A–D). B-cell and Ig changes. Mean changes in total CD3-CD20+ B-cells (A) and immunoglobulin (Ig) subclasses levels (B-D) were measured over 24 weeks of treatment. Mean per cent changes are based on the safety population. 120/Q4W=120 mg subcutaneous (SQ) tabalumab injection every 4 weeks; 90/Q2W=90 mg SQ tabalumab injection every 2 weeks; mLOCF=modified last observation carried forward. *p<0.001 tabalumab groups versus placebo (both comparisons) at week 24 (mLOCF).
