Table 3.

Summary of ch-mAb7F9 pharmacokinetic parameters by treatment

	AUC(0-inf) (μg*h/mL)	AUC(0-last) (μg*h/mL)	Cmax (μg/mL)	tmaxa (h)	t1/2 (h)	CL (L/h)	Vd (L)
0.2 mg/kg
n	6	6	6	6	6	6	6
Mean	1400	1070	5.21	3.18 (2.03, 4.00)	341	0.0104	5.01
SD	200	214	1.82	—	74.1	0.00173	0.652
0.6 mg/kg
n	6	6	6	6	6	6	6
Mean	4620	4160	15.5	2.25 (2.25, 6.00)	383	0.0101	5.38
SD	714	690	2.33	—	128	0.00204	1.73
2 mg/kg
n	5	5	6	6	5	5	5
Mean	16800	16300	50.6	3.52 (2.25, 6.00)	432	0.00794	5.03
SD	1520	1500	3.43	—	57.4	0.00134	1.43
6 mg/kg
n	6	6	6	6	6	6	6
Mean	53500	53000	178	3.50 (2.00, 6.00)	418	0.00855	5.14
SD	4640	4640	16.5	—	51.5	0.00109	0.743
20 mg/kg
n	6	6	7	7	6	6	6
Mean	166000	165000	517	2.28 (2.00, 4.02)	460	0.00896	5.88
SD	17700	17500	89.3	—	42.0	0.00273	1.51

Note(s): n = number of subjects; SD = standard deviation. ^aOnly median (minimum, maximum) are presented for t_max.