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. 2014 Dec 23;15(12):1688–1699. doi: 10.4161/15384047.2014.972799

Figure 5.

Figure 5.

KS18 and ABT-737 synergize to reduce HL60/ABTR xenograft tumor growth in athymic nude mice. (A) Female athymic nude mice bearing HL60/ABTR xenograft tumors were treated with vehicle, ABT-737 (20 mg/kg), KS18 (10 mg/kg), or both ABT-737 and KS18 at 20 mg/kg and 10 mg/kg respectively, for 14 consecutive days after tumor staging. Tumor volumes were measured every 2 days. Error bars = SEM of 10–20 xenograft tumors. n.s. = not statistically significant, **P <0.005, ***P <0.0005 by Student's T-test of tumor volumes at day 14. Combination index between ABT-737 and KS18 was calculated based on perecent tumor size of vehicle control at each day (right). Combination index <1 signifies synergy. (B) The average body weights of mice bearing HL60/ABTR xenograft tumors expressed as a percentage of day 0.