Table 2.
The EC50 values of the indicated cell lines treated with the indicated compounds over 48 hours, *28 hours, **24 hours
| EC50 (μM) | Maritoclax | KS04 | KS17 | KS18 | KS19 | KS20 | KS24 | ABT-737 | Daunorubicin |
|---|---|---|---|---|---|---|---|---|---|
| K562/Mcl-1-IRES-Bim | 0.99 | 1.41 | 1.13 | 0.60* | 0.41 | 0.55 | 0.58 | 9.3** | |
| K562/Bcl-2-IRES-Bim | >20 | >25 | >20 | >50* | 0.35** | ||||
| Jurkat | 2.53 | 2.97 | 1.15 | 1.21 | 1.68 | 0.66 | |||
| JurkatΔBak | >15 | >20 | >25 | >25 | >25 | >50 | |||
| HL60/VCR | 1.67 | 1.35 | 1.17 | 0.69 | 0.66 | 0.71 | >50 | 30.41 | |
| HL60/ABTR | 2.15 | 3.03 | 1.63 | 0.73 | 0.80 | 0.83 | 1.83 | >100 | 12.17 |
| Kasumi-1 | 1.80 | 6.70 | 1.47 | 0.01 | |||||
| Kasumi-1/ABT | 2.15 | 2.91 | 0.70 | 0.51 | 0.46 | ||||
| THP-1 | 6.31 | 3.74 | 1.96 | 1.27 | 0.065 | ||||
| U937 | 1.23 | 1.66 | 1.77 | 0.54 | 0.50 | 0.67 | 0.57 | 5.29 | 0.86 |
| C1498 | 1.66 | 1.12 | 0.70 | 0.85 | 0.68 | 6.13 | 1.92 | ||
| RPMI 8226 | 2.68 | 1.87 | 0.94 | 0.72 | 0.58 | 0.57 | 0.25 | 0.23 | |
| MM.1S | 3.72 | 1.92 | 1.71 | 0.79 | 0.68 | 0.69 | 0.40 | 0.12 | |
| NCI-H929 | 1.47 | 1.00 | 1.30 | 0.72 | 0.74 | 0.73 | 15.21 | 0.24 | |
| U266 | 2.15 | 2.04 | 0.90 | 0.68 |