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The pharmacokinetic parameters of maritoclax and KS18 by intraperitoneal injection in female BALB/c mice
| Maritoclax (i.p.) 10 mg/kg | KS18 (i.p.) 5 mg/kg | |
|---|---|---|
| T1/2 (hours) | 3.47 | 2.78 |
| Tmax (hours) | 2.0 | 0.50 |
| Cmax (ng/mL) | 1536.16 | 14268.36 |
| AUClast (hr*ng/mL) | 5408.65 | 14311.68 |
| AUCINF_OBS (hr*ng/mL) | 5418.96 | 14321.47 |
| VD (mL/kg) | 9239.86 | 1401.30 |
| CL (mL/hour/kg) | 1845.37 | 349.13 |
