Table 4.

Antimicrobial MIC distributions for the V. cholerae and V. vulnificus isolates tested.

Antimicrobial agent	Test range (mg/L)	Breakpointsa (mg/L)			MIC (mg/L) distribution for V. vulnificus (n = 141)			MIC (mg/L) distribution for V. cholerae (n = 184)
		S	I	R	MIC50	MIC90	Range	MIC50	MIC90	Range
Ampicillin	0.5–32	≤ 8	16	≥32	1	2	≤ 0.5–2	2	8	≤ 0.5–>32
Cefotaxime	0.06–4	≤ 1	2	≥4	≤ 0.06	≤ 0.06	≤ 0.06–0.12	≤ 0.06	≤ 0.06	≤ 0.06–0.12
Ceftazidime	0.25–16	≤ 4	8	≥16	≤ 0.25	≤ 0.25	≤ 0.25–0.5	≤ 0.25	≤ 0.25	≤ 0.25–0.5
Chloramphenicol	2–64	≤ 8	16	≥32	≤ 2	≤ 2	≤ 2	≤ 2	≤ 2	≤ 2
Ciprofloxacin	0.008–8	≤ 1	2	≥4	0.015	0.03	≤ 0.008–0.06	≤ 0.008	≤ 0.008	≤ 0.008–0.5
Florfenicol	2–64	≤ 4	8	≥16	≤ 2	≤ 2	≤ 2	≤ 2	≤ 2	≤ 2
Gentamicin	0.25–32	≤ 4	8	≥16	2	2	0.5–4	1	2	≤ 0.25–4
Kanamycin	4–128	≤ 16	32	≥64	8	16	≤ 4–32	≤ 4	8	≤ 4–16
Nalidixic acid	4–64	≤ 16		≥32	≤ 4	≤ 4	≤ 4–8	≤ 4	≤ 4	≤ 4–>64
Streptomycin	2–128	≤ 16	32	≥64	16	32	4–64	16	32	8–64
Tetracycline	1–64	≤ 4	8	≥16	≤ 1	≤ 1	≤ 1–2	≤ 1	≤ 1	≤ 1
Trimethoprim	0.5–32	≤ 8		≥16	1	1	≤ 0.5–4	≤ 0.5	1	≤ 0.5–>32

S, susceptible; I, intermediate resistant; R, resistant.

^aCriteria used for interpretation and corresponding references are given in Supplementary Table S3.